FRETting over kinesin activity
نویسندگان
چکیده
منابع مشابه
Kinesin walks hand-over-hand.
Kinesin is a processive motor that takes 8.3-nm center-of-mass steps along microtubules for each adenosine triphosphate hydrolyzed. Whether kinesin moves by a "hand-over-hand" or an "inchworm" model has been controversial. We have labeled a single head of the kinesin dimer with a Cy3 fluorophore and localized the position of the dye to within 2 nm before and after a step. We observed that singl...
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Fretting corrosion is a form of accelerated atmospheric oxidation which occurs at the interface of contacting materials undergoing slight, cyclic relative motion. In electric contacts involving non-noble metals, fretting action can cause rapid increases in contact resistance, proceeding to virtual open circuits in a matter of minutes in the worst cases. Experimental results of resistance increa...
متن کاملOn the hand-over-hand mechanism of kinesin.
We present here a simple theoretical model for conventional kinesin. The model reproduces the hand-over-hand mechanism for kinesin walking to the plus end of a microtubule. A large hindering force induces kinesin to walk slowly to the minus end, again by a hand-over-hand mechanism. Good agreement is obtained between the calculated and experimental results on the external force dependence of the...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2033iti2